Mitotane

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Chemical Information

Product name：Mitotane	Purity：99% min
CAS NO：53-19-0	Solubility：DMSO : ≥ 100 mg/mL (312.46 mM)
Molecular Formula：C₁₄H₁₀Cl₄	Package：Package according to customer requirements
Molecular Weight：408.512	Storage：Store at -20℃

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Remarks

Mitotane is a synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production.

Properties:
Appearance & Physical State: Crystalline Solid
Density: 1.372 g/cm3
Boiling Point: 398.9ºC at 760 mmHg
Melting Point: 76-78ºC
Flash Point: 194.2ºC
Storage Condition: APPROX 4ºC

References

[1]. Gentilin E, Tagliati F, Terzolo M, Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function. J Endocrinol. 2013 Jul 29;218(3):275-285.

[2]. Lehmann TP, Wrzesiński T, Jagodziński PP. The effect of mitotane on viability, steroidogenesis and gene expression in NCI H295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.