LY500307 Erteberel

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Chemical Information

Product name：LY500307 Erteberel	Purity：98% min
CAS NO：533884-09-2	Solubility：
Molecular Formula：C₁₈H₁₈O₃	Package：Package according to customer requirements
Molecular Weight：282.334	Storage：Store at -20℃

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Remarks

Erteberel, also known as LY500307, is a selective estrogen receptor beta (ERβ) agonist that was developed for the treatment of benign prostatic hyperplasia. LY500307 was well tolerated in BPH patients with LUTS at doses up to 25 mg once daily for 24 weeks. The study was terminated early because of inadequate efficacy.

References

[1]. Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.

[2]. Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185.