5-Aminolevulinic acid hydrochloride

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Chemical Information

Product name：5-Aminolevulinic acid hydrochloride	Purity：98% min
CAS NO：5451-09-2	Solubility：DMSO : ≥ 150 mg/mL (895.04 mM)
Molecular Formula：C₅H₁₀ClNO₃	Package：Package according to customer requirements
Molecular Weight：167.591	Storage：Store at -20℃

Quality control

Remarks

Aminolevulinic acid, also known as ALA, is a topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. In 1999, FDA approved this drug for for actinic keratosis.

Properties:
Appearance & Physical State: white to pale yellow crystals or
Melting Point: ~150 °C (dec.)
Flash Point: 155-157°C
Storage Condition: 2-8°C

References

[1]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.

[2]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.