cefmetazole

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Chemical Information

Product name：cefmetazole	Purity：98% min
CAS NO：56796-20-4	Solubility：Soluble in DMSO
Molecular Formula：C₁₅H₁₇N₇O₅S₃	Package：Package according to customer requirements
Molecular Weight：471.534	Storage：Store at -20℃

Quality control

Remarks

Cefmetazole is a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs) that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Properties
Density: 1.75 g/cm3
Melting Point: 163-165ºC
Refractive Index: 1.797
Storage Condition: 2-8ºC

References

1: Matsumura Y, Yamamoto M, Nagao M, Tanaka M, Takakura S, Ichiyama S. In vitro
activities and detection performances of cefmetazole and flomoxef for
extended-spectrum β-lactamase and plasmid-mediated AmpC β-lactamase-producing
Enterobacteriaceae. Diagn Microbiol Infect Dis. 2015 Dec 11. pii:
S0732-8893(15)00438-1. doi: 10.1016/j.diagmicrobio.2015.12.001. [Epub ahead of
print] PubMed PMID: 26782634.

2: Matsumura Y, Yamamoto M, Nagao M, Komori T, Fujita N, Hayashi A, Shimizu T,
Watanabe H, Doi S, Tanaka M, Takakura S, Ichiyama S. Multicenter retrospective
study of cefmetazole and flomoxef for treatment of
extended-spectrum-β-lactamase-producing Escherichia coli bacteremia. Antimicrob
Agents Chemother. 2015 Sep;59(9):5107-13. doi: 10.1128/AAC.00701-15. Epub 2015
Jun 22. PubMed PMID: 26100708; PubMed Central PMCID: PMC4538479.