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Product :

Erastin

Erastin 571203-78-6
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Chemical Information
Product name:Erastin Purity:98% min
CAS NO:571203-78-6 Solubility:DMSO : 6.4 mg/mL (11.70 mM)
Molecular Formula:C30H31ClN4O4 Package:Package according to customer requirements
Molecular Weight:547.045 Storage:Store at -20℃
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Remarks

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism.

 

 

 

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