Nisoxetine hydrochloride

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Chemical Information

Product name：Nisoxetine hydrochloride	Purity：98% min
CAS NO：57754-86-6	Solubility：
Molecular Formula：C₁₇H₂₂ClNO₂	Package：Package according to customer requirements
Molecular Weight：307.815	Storage：-20℃

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Remarks

Nisoxetine hydrochloride is a potent and selective noradrenaline transporter (NET) inhibitor with Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic that blocks voltage-gated sodium channels.

References

[1]. Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32.

[2]. Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70.