Tasimelteon BMS-214778

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Chemical Information

Product name：Tasimelteon BMS-214778	Purity：99.8% min
CAS NO：609799-22-6	Solubility：DMSO : ≥ 33 mg/mL (134.52 mM)
Molecular Formula：C₁₅H₁₉NO₂	Package：Package according to customer requirements
Molecular Weight：245.317	Storage：Store at -20℃

Quality control

Remarks

Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleepÂ–wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved.

Properties:
Density: 1.145
Boiling Point: 442.553ºC at 760 mmHg
Flash Point: 221.448ºC
Refractive Index: 1.564

References

[1]. Leger D, et al. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14(11):1673-85.

[2]. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.