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RGX-104 610318-54-2
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Chemical Information
Product name:RGX-104 Purity:98% min
CAS NO:610318-54-2 Solubility:DMSO : 100 mg/mL (167.76 mM; Need ultrasonic)
Molecular Formula:C34H33ClF3NO3 Package:Package according to customer requirements.
Molecular Weight:596.079 Storage:-20℃
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RGX-104, also known as SB 742881, is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.

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