Potassium clavulanate

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Chemical Information

Product name：Potassium clavulanate	Purity：98% min
CAS NO：61177-45-5	Solubility：Soluble in DMSO, not in water
Molecular Formula：C₈H₈KNO₅	Package：Package according to customer requirements
Molecular Weight：237.251	Storage：Store at 2-8ºC

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Remarks

Clavulanate potassium is an acid which is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but when combined with penicillin-group antibiotics it prevents antibiotic inactivation by microbial lactamase. It is commonly combined with amoxicillin or ticarcillin.

Properties:
Appearance & Physical State: Pale Yellowish Solid
Boiling Point: 545.8ºC at 760 mmHg
Melting Point: >160ºC
Flash Point: 283.9ºC

References

[1]. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11(5): 852–857.

[2]. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23(4):547-56.