VU0364770

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Chemical Information

Product name：VU0364770	Purity：99% min
CAS NO：61350-00-3	Solubility：DMSO : ≥ 100 mg/mL (429.79 mM)
Molecular Formula：C₁₂H₉ClN₂O	Package：Packaging according to customer requirements
Molecular Weight：232.666	Storage：Store at -20℃

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Remarks

VU0364770 is a Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

GluR Inhibitors Related Prodcuts:

CTEP (RO4956371); MPEP; NBQX (FG9202)

References

[1]. Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.