NLX-101 F-15599

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Chemical Information

Product name：NLX-101 F-15599	Purity：98% min
CAS NO：635323-95-4	Solubility：DMSO : 250 mg/mL (633.15 mM)
Molecular Formula：C₁₉H₂₁ClF₂N₄O	Package：Package according to customer requirements
Molecular Weight：394.846	Storage：Store at -20℃

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Remarks

NLX-101, also known as F-15,599, is a novel compound that activates serotonin 5-HT1A receptors with exceptional selectivity, having over 1000-fold higher affinity for this target over other receptors. In addition, NLX-101 is a 'biased agonist' at 5-HT1A receptors, preferentially activating 5-HT1A receptors in those brain regions that control mood and cognition.

References

[1]. Meadows SM, et al. Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia. Exp Neurol. 2017 Jun;292:168-178.

[2]. de Boer SF, et al. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT?A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology (Berl). 2016 Mar;233(6):937-47.