Halofuginone Hydrobromide

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Chemical Information

Product name：Halofuginone Hydrobromide	Purity：99% min
CAS NO：64924-67-0	Solubility：DMSO : 50 mg/mL (100.89 mM)
Molecular Formula：C₁₆H₁₈Br₂ClN₃O₃	Package：Package according to customer requirements
Molecular Weight：495.593	Storage：Store at -20℃

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Remarks

Halofuginone hydrobromide (RU-19110 hydrobromide) is a less-toxic form of Febrifugine, which is isolated from the plant Dichroa febrifuga. Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity.

Properties:
Boiling Point 595.8ºC at 760 mmHg
Flash Point 314.1ºC

Related Prodcuts:

Vidarabine; Flupirtine maleate; Rifampicin; Rifaximin; Rifapentine; Streptozocin; Tegafur

References

[1]. Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247.

[2]. Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.