Ansamitocin P-3

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Chemical Information

Product name：Ansamitocin P-3	Purity：98% min
CAS NO：66584-72-3	Solubility：DMSO : ≥ 100 mg/mL (157.45 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₃₂H₄₃ClN₂O₉	Package：Package according to customer requirements
Molecular Weight：635.145	Storage：Store at -20℃

Quality control

COA

Remarks

Ansamitocin P-3 (AP-3) is an active and potent anti-tumor maytansinoid, which is usually produced by Actinosynnema spp. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. Ansamitocin P-3 is a useful material to make anticancer drug mertansine and emtansine.

Properties:
Density: 1.29g/cm3
Boiling Point: 833.1ºC at 760 mmHg
Flash Point: 457.7ºC
Refractive Index: 1.583

References

[1]. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48.

[2]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.