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PX-478

PX-478 685898-44-6
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Chemical Information
Product name:PX-478 Purity:98% min
CAS NO:685898-44-6 Solubility:H2O : ≥ 35 mg/mL (88.81 mM)
Molecular Formula:C13H20Cl4N2O3 Package:Package according to customer requirements
Molecular Weight:394.122 Storage:Store at -20℃
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Remarks
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). 
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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