CP-945598 Otenabant HCl

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Chemical Information

Product name：CP-945598 Otenabant HCl	Purity：98% min
CAS NO：686347-12-6	Solubility：10 mM in DMSO
Molecular Formula：C₂₅H₂₆Cl₃N₇O	Package：Package according to customer requirements
Molecular Weight：546.879	Storage：Store at -20℃

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Remarks

Otenabant, also known as CP-945,598, is a drug which acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.

References

[1]. John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371.

[2]. Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5