Aniracetam (RO 13-5057)

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Chemical Information

Product name：Aniracetam (RO 13-5057)	Purity：98% min
CAS NO：72432-10-1	Solubility：DMSO : ≥ 100 mg/mL (456.12 mM)
Molecular Formula：C₁₉H₁₇N₇O₃	Package：Package according to customer requirements
Molecular Weight：219.237	Storage：Store at -20℃

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Remarks

Aniracetam, also known as Ampamet and Ro-13-5057, is a pyrrolidinone-type cognition enhancer that has been clinically used in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer's disease. Aniracetam appears to positively modulate metabotropic glutamate receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptors, and may facilitate cholinergic transmission, effects which are possibly related to its mechanism of action.

Properties:
Appearance & Physical State: White Crystalline or Crystalline Powde
Density: 1.236 g/cm3
Boiling Point: 399.7ºC at 760 mmHg
Melting Point: 119-122ºC
Flash Point: 195.5ºC
Refractive Index: 1.573
Vapor Density: 4.9

References

[1]. Nakamura K, et al. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.

[2]. Vaglenova J, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4.