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K-858 Racemic

K-858 Racemic 72926-24-0
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Chemical Information
Product name:K-858 Racemic Purity:98% min
CAS NO:72926-24-0 Solubility:DMSO : 100 mg/mL (360.57 mM); H2O : < 0.1 mg/mL
Molecular Formula:C13H15N3O2S Package:Package according to customer requirements
Molecular Weight:277.342 Storage:Store at +4°C
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Remarks
K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death, and polyploidization followed by senescence. K858 exhibited potent antitumor activity in xenograft models of cancer, and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.
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