TAK-385 Relugolix

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Chemical Information

Product name：TAK-385 Relugolix	Purity：98% min
CAS NO：737789-87-6	Solubility：DMSO : 50 mg/mL (80.18 mM)
Molecular Formula：C₂₉H₂₉F₂N₇O₅S	Package：Package according to customer requirements
Molecular Weight：625.646	Storage：-20℃

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Remarks

Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.

Related Prodcuts:

Relugolix Intermediate(308831-94-9)

References

[1]. MacLean DB et al. Medical Castration Using the Investigational Oral GnRH Antagonist TAK-385 (Relugolix): Phase 1 Study in Healthy Males. J Clin Endocrinol Metab. 2015 Dec;100(12):4579-87.

[2]. Nakata D et al. Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice. Eur J Pharmacol. 2014 Jan 15;723:167-74.