Aclarubicin hydrochloride

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Chemical Information

Product name：Aclarubicin hydrochloride	Purity：98% min
CAS NO：75443-99-1	Solubility：DMSO : ≥ 125 mg/mL (147.35 mM)
Molecular Formula：C₄₂H₅₄ClNO₁₅	Package：Package according to customer requirements
Molecular Weight：848.329	Storage：Store at 2-8°C

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Remarks

Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.

Properties:
Boiling Point: 897.7ºC at 760 mmHg
Flash Point: 496.7ºC
Storage Condition: 2-8ºC

References

[1]. Isoe T, et al. Inhibition of different steps of the ubiquitin system by CDDP and aclarubicin. Biochim Biophys Acta. 1992 Sep 15;1117(2):131-5.

[2]. Hajji N, et al. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2;583(1):26-35.