TAE684 (NVP-TAE684)

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Chemical Information

Product name：TAE684 (NVP-TAE684)	Purity：98% min
CAS NO：761439-42-3	Solubility：10 mM in DMSO
Molecular Formula：C₃₀H₄₀ClN₇O₃S	Package：Package according to customer requirements
Molecular Weight：614.202	Storage：Store at -20℃

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Remarks

TAE684, also known as NVP-TAE684, is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM . TAE684 is also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).

References

[1]. Galkin AV, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.

[2]. Katayama R, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40.