Chlorthalidone is a diuretic drug used to treat hypertension. It is described as a thiazide diuretic. Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. Chlortalidone is often used in the management of hypertension and edema. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water.
Properties:
Appearance & Physical State: White to yellowish-white crystalline powder. Odorless.
Density: 1.601g/cm3
Melting Point: 265-267ºC (dec.)
Refractive Index: 1.694
Stability: Stable under normal temperatures and pressures.
Storage Condition: 2-8ºC