GNF-2

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：GNF-2	Purity：98% min
CAS NO：778270-11-4	Solubility：DMSO : ≥ 45 mg/mL (120.22 mM)
Molecular Formula：C₁₈H₁₃F₃N₄O₂	Package：Package according to customer requirements
Molecular Weight：374.317	Storage：Store at -20℃

Quality control

Remarks

GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. Selective for Bcr-abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Properties:
Density: 1.405g/cm3
Boiling Point: 536.4ºC at 760 mmHg
Flash Point: 278.2ºC
Refractive Index: 1.611

References

[1]. Adrián FJ, et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2(2):95-102.

[2]. Khateb M, et al. Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism. BMC Cancer. 2012 Nov 27;12:563.