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YM-155 Sepantronium bromide

YM-155 Sepantronium bromide 781661-94-7
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Chemical Information
Product name:YM-155 Sepantronium bromide Purity:98% min
CAS NO:781661-94-7 Solubility:DMSO : 10.66 mg/mL (24.05 mM)
Molecular Formula:C20H19BrN4O3 Package:Package according to customer requirements
Molecular Weight:443.294 Storage:Store at -20℃
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Sepantronium bromide, also known as YM-155, is a small-molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.
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