L-165041

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Chemical Information

Product name：L-165041	Purity：98% min
CAS NO：79558-09-1	Solubility：DMSO : 50 mg/mL (124.24 mM)
Molecular Formula：C₂₂H₂₆O₇	Package：Package according to customer requirements
Molecular Weight：402.438	Storage：Store at -20℃

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Remarks

L-165041, also known as L-165,041, is a potent and selective agonist of the nuclear receptor PPARβ/δ (Ki = 9 nM, EC50 = ~500 nM for hPPARβ/δ). L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism. L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle.

References

[1]. Berger J, et al. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25.

[2]. Park, Jin-Hee., et al. The PPARδ ligand L-165041 inhibits vegf-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. Journal of Cellular Biochemistry (2012), 113(6), 1947-1954.

[3]. Lim, Hyun-Joung., et al. PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice. European Journal of Pharmacology (2009), 622(1-3), 45-51.