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GSK180736A

GSK180736A 817194-38-0
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Chemical Information
Product name：GSK180736A Purity：98% min
CAS NO：817194-38-0 Solubility：DMSO : ≥ 30 mg/mL (82.11 mM)
Molecular Formula：C19H16FN5O2 Package：Package according to customer requirements
Molecular Weight：365.3684 Storage：Store at -20℃
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Remarks
GSK180736A is potent and selective inhibitor of GRK2 with an IC50 of 0.77 μM25 and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM).
References
[1]. Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016 Apr 28;59(8):3793-807.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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