AS1842856

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Chemical Information

Product name：AS1842856	Purity：98% min
CAS NO：836620-48-5	Solubility：DMSO : 5 mg/mL (14.39 mM)
Molecular Formula：C₁₈H₂₂FN₃O₃	Package：Package according to customer requirements
Molecular Weight：347.384	Storage：-20 ℃

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Remarks

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.

References

[1]. Nagashima T, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70.

[2]. He J, et al. The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep. 2019 May 10;39(5). pii: BSR20190112.