Product :
WH-4-023
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Chemical Information
Product name:WH-4-023 |
Purity:98% min |
CAS NO:837422-57-8 |
Solubility:DMSO : ≥ 46.8 mg/mL (82.30 mM) |
Molecular Formula:C32H36N6O4 |
Package:Package according to customer requirements |
Molecular Weight:568.666 |
Storage:Store at -20℃ |
Remarks
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively. The lymphocyte-specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation.