Cetirizine

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Chemical Information

Product name：Cetirizine	Purity：98% min
CAS NO：83881-51-0	Solubility：Soluble in DMSO
Molecular Formula：C₂₁H₂₅ClN₂O₃	Package：Package according to customer requirements
Molecular Weight：388.888	Storage：Store at -20℃

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Remarks

Cetirizine is a second-generation antihistamine used in the treatment of hay fever, allergies, angioedema, and urticaria. It is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist.
Second-generation antihistamines like cetirizine are less able to cross the blood-brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs: for instance they are less likely to induce drowsiness or to interfere with memory formation.

Properties:
Appearance & Physical State: white to off-white crystalline powder
Density: 1.237 g/cm3
Boiling Point: 542.1ºC at 760 mmHg
Melting Point: 110-115ºC
Flash Point: 281.6ºC
Water Solubility: 101 mg/L

References

[1]. Hair PI, Scott LJ. Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. Drugs. 2006;66(7):973-96.

[2]. Day JH, Ellis AK, Rafeiro E. Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders. Drugs Today (Barc). 2004 May;40(5):415-21.