A-769662

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Chemical Information

Product name：A-769662	Purity：98% min
CAS NO：844499-71-4	Solubility：DMSO : 24 mg/mL (66.59 mM)
Molecular Formula：C₂₀H₁₂N₂O₃S	Package：Package according to customer requirements
Molecular Weight：360.386	Storage：Store at -20℃

Quality control

COA

Remarks

A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator with an EC50 of 0.8 μM.A-769662 displays selectivity towards β1 subunit-containing heterotrimers.

References

[1]. Cool B, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab, 2006, 3(6), 403-416.

[2]. Sanders MJ, et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem, 2007, 282(45), 32539-32548.