SHA-68

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Chemical Information

Product name：SHA-68	Purity：98% min
CAS NO：847553-89-3	Solubility：DMSO : 250 mg/mL (561.18 mM)
Molecular Formula：C₂₆H₂₄FN₃O₃	Package：Package according to customer requirements
Molecular Weight：445.485	Storage：-20 ℃

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Remarks

SHA 68 is a potent and selective antagonist of non-peptide neuropeptide S receptor (NPSR) with IC50 of 22.0 nM and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 limits the blood-brain barrier (BBB) penetration and the activity in neuralgia.

References

[1]. Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.

[2]. Ensho T, et al. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.Neuropeptides. 2017 Oct;65:21-27.