EMD534085

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Chemical Information

Product name：EMD534085	Purity：98% min
CAS NO：858668-07-2	Solubility：DMSO : ≥ 26 mg/mL (54.56 mM)
Molecular Formula：C₂₅H₃₁F₃N₄O₂	Package：Package according to customer requirements
Molecular Weight：476.5340	Storage：Store at -20℃

Quality control

Remarks

EMD534085 is a kinesin inhibitor currently in clinical development.

References

[1]. Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.

[2]. Tang Y, et al. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1;310(1):15-24.