PSI-6206

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Chemical Information

Product name：PSI-6206	Purity：98% min
CAS NO：863329-66-2	Solubility：DMSO : 100 mg/mL (384.29 mM)
Molecular Formula：C₁₀H₁₃FN₂O₅	Package：Package according to customer requirements
Molecular Weight：260.219	Storage：Store at -20℃

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Remarks

GS-331007, also known as PSI-6206 and RO-2433, is a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

References

[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8.

[2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29

[3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.