ML-180

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Chemical Information

Product name：ML-180	Purity：98% min
CAS NO：863588-32-3	Solubility：DMSO : 11.9 mg/mL (30.60 mM)
Molecular Formula：C₂₀H₂₅ClN₄O₂	Package：Package according to customer requirements
Molecular Weight：388.891	Storage：-20℃

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Remarks

ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 µM). ML-180 has the potential for LRH-1-dependent cancers.

References

[1]. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2).

[2]. Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304.