Narlaprevir

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Narlaprevir	Purity：98% min
CAS NO：865466-24-6	Solubility：DMSO : ≥ 50 mg/mL (70.63 mM)
Molecular Formula：C₃₆H₆₁N₅O₇S	Package：Package according to customer requirements
Molecular Weight：707.964	Storage：Store at -20℃

Quality control

Remarks

Narlaprevir, also known as SCH-900518, is a potent and second generation inhibitor of HCV NS3 protease with Ki value of 6 nM. Narlaprevir forms a reversible covalent bond with the active-site serine. It has an overall inhibition constant (K*(i)) of 7 nM and a dissociation half-life of 1 to 2 h. SCH 900518 inhibited replicon RNA at a 90% effective concentration (EC(90)) of 40 nM.

References

[1]. Ashok Arasappan, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med. Chem. Lett., 2010, 1 (2), pp 64–69

[2]. Tong X, Arasappan A, Bennett F, Chase R, Feld B, Guo Z, Hart A, Madison V, Malcolm B, Pichardo J, Prongay A, Ralston R, Skelton A, Xia E, Zhang R, Njoroge FG.Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mecha