PLX647

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Chemical Information

Product name：PLX647	Purity：99% min
CAS NO：873786-09-5	Solubility：DMSO : ≥ 31 mg/mL (81.07 mM)
Molecular Formula：C₂₁H₁₇F₃N₄	Package：Package according to customer requirements
Molecular Weight：382.382	Storage：Store at -20℃

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Remarks

PLX-647 is PLX647 is a potent inhibitors of both FMS and KIT that show strong selectivity compared with other kinases. In the in vitro enzymatic assay, PLX647 inhibits FMS with IC50 = 0.028μM and KIT with IC50 = 0.016 μM. PLX647 represents a unique class of kinase inhibitors with unique dual FMS and KIT specificity.

References

[1]. Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94.

[2]. Louvet C, et al. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18895-900.