XL647 Tesevatinib

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Chemical Information

Product name：XL647 Tesevatinib	Purity：98% min
CAS NO：874286-84-7	Solubility：DMSO : ≥ 30 mg/mL (61.05 mM)
Molecular Formula：C₂₄H₂₅Cl₂FN₄O₂	Package：Package according to customer requirements
Molecular Weight：491.385	Storage：Store at -20℃

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Remarks

Tesevatinib, also known as XL647, EXEL-7647 and KD-019, is a n orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.

References

1: Stasi I, Cappuzzo F. Second generation tyrosine kinase inhibitors for the treatment of metastatic non-small-cell lung cancer. Transl Respir Med. 2014 Jan 6;2:2. doi: 10.1186/2213-0802-2-2. eCollection 2014. PubMed PMID: 25505694; PubMed Central PMCID: PMC4215821.

2: Yu HA, Riely GJ. Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in lung cancers. J Natl Compr Canc Netw. 2013 Feb 1;11(2):161-9. PubMed PMID: 23411383; PubMed Central PMCID: PMC3673302.