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LXR-623 WAY-252623

LXR-623 WAY-252623 875787-07-8
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Chemical Information
Product name:LXR-623 WAY-252623 Purity:98% min
CAS NO:875787-07-8 Solubility:DMSO : ≥ 47 mg/mL (111.17 mM)
Molecular Formula:C21H12ClF5N2 Package:Packaging according to customer requirements
Molecular Weight:422.778 Storage:Store at -20℃
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Remarks

LXR623, also known as WAY-252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR(-/-) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significantly reduced total (50-55%) and LDL-cholesterol (LDLc) (70-77%) in a time- and dose-dependent manner as well as increased expression of the target genes ABCA1/G1 in peripheral blood cells.

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