Lesinurad RDEA594

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Chemical Information

Product name：Lesinurad RDEA594	Purity：99.0% min
CAS NO：878672-00-5	Solubility：DMSO: ≥ 39 mg/mL
Molecular Formula：C₁₇H₁₄BrN₃O₂S	Package：Package according to customer requirements
Molecular Weight：404.28096	Storage：Store at -20℃

Quality control

COA

Remarks

Lesinurad, also known as RDEA594, is a selective uric acid re-absorption inhibitor (SURI) and is also a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. RDEA594 has been shown to normalize the amount of uric acid excreted by gout patients previously classified as under-excretors. Lesinurad received FDA approval on December 22, 2015.

References

[1]. Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52.

[2]. Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59.