Pilsicainide hydrochloride

Pilsicainide, also known as SUN 1165, is a drug used clinically in Japan to treat cardiac arrhythmias. It functions by blocking the fast inward movement of sodium ions through the Nav1.5 sodium channel that contributes to the rapid depolarization characteristic of phase 0 in the cardiac action potential. Pilsicainide is a pure sodium channel blocker, meaning it does not significantly affect any other cardiac channels including potassium and calcium channels.

Properties:
Boiling Point: 416.9ºC at 760 mmHg
Flash Point: 205.9ºC

1: Yamasaki H, Tada H, Sekiguchi Y, Aonuma K. Right coronary cusp as a new window of ablation for pilsicainide-induced ventricular premature contractions in a patient with Brugada syndrome. Heart Vessels. 2016 Aug;31(8):1397-401. doi: 10.1007/s00380-015-0760-3. PubMed PMID: 26510553.

2: Shimizu M, Hashiguchi M, Shiga T, Nakamura K, Tamura HO, Mochizuki M. Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:172-9. doi: 10.1016/j.jchromb.2015.01.013. PubMed PMID: 25687803.