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KU 0060648

KU 0060648 881375-00-4
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Chemical Information
Product name：KU 0060648 Purity：98% min
CAS NO：881375-00-4 Solubility：Soluble in DMSO
Molecular Formula：C33H34N4O4S Package：Package according to customer requirements
Molecular Weight：582.712 Storage：Store at -20℃
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Remarks

KU-0060648 is a dual inhibitor of DNA-PK and PI-3K. KU-0060648 inhibited cellular DNA-PK autophosphorylation with IC(50) values of 0.019 μmol/L (MCF7 cells) and 0.17 μmol/L (SW620 cells), and PI-3K-mediated AKT phosphorylation with IC(50) values of 0.039 μmol/L (MCF7 cells) and more than 10 μmol/L (SW620 cells). KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.


References
  • [1] Munck JM, et al. Mol Cancer Ther, 2012, 11(8), 1789-1798.
  • [2] Celine Cano, et al. Mol Cancer Ther, 2009, 8(12 Suppl), A138
    • Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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