INCB 3284 dimesylate

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Chemical Information

Product name：INCB 3284 dimesylate	Purity：98% min
CAS NO：887401-93-6	Solubility：DMSO : ≥ 83.3 mg/mL (116.87 mM)
Molecular Formula：C₂₈H₃₉F₃N₄O₁₀S₂	Package：Package according to customer requirements
Molecular Weight：712.755	Storage：Store at -20℃

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Remarks

INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.

References

[1]. Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2(6):450-4.

[2]. McMillin M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.