Product :
INNO-406 Bafetinib
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Chemical Information
| Product name：INNO-406 Bafetinib |
Purity：98% min |
| CAS NO：887650-05-7 |
Solubility：10 mM in DMSO |
| Molecular Formula：C30H31F3N8O |
Package：Package according to customer requirements |
| Molecular Weight：576.615 |
Storage：Store at -20℃ |
Remarks
Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types.