DMOG Dimethyloxaloylglycine

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Chemical Information

Product name：DMOG Dimethyloxaloylglycine	Purity：98% min
CAS NO：89464-63-1	Solubility：DMSO : ≥ 101.5 mg/mL (579.54 mM)
Molecular Formula：C₆H₉NO₅	Package：Package according to customer requirements
Molecular Weight：175.139	Storage：Store at -20℃

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Remarks

DMOG, also known as Dimethyloxaloylglycine, is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG provides neuroprotection after traumatic brain injury. DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis.

Properties:
Density: 1.247g/cm3
Melting Point: 46-48ºC
Refractive Index: 1.44
Storage Condition: Refrigerator

References

[1]. Baader E, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 (Pt 2):525-30.

[2]. Milkiewicz M, et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560(Pt 1):21-6.