PF-3274167 cligosiban

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Chemical Information

Product name：PF-3274167 cligosiban	Purity：98% min
CAS NO：900510-03-4	Solubility：DMSO : ≥ 50 mg/mL (119.09 mM)
Molecular Formula：C₁₉H₁₉ClFN₅O₃	Package：Package according to customer requirements
Molecular Weight：419.837	Storage：Store at -20℃

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Remarks

PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. Oxytocin receptors are also present in the central nervous system. These receptors modulate a variety of behaviors, including stress and anxiety, social memory and recognition, sexual and aggressive behaviors, bonding (affiliation) and maternal behavior.

References

[1]. Karpenko IA, et al. Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay. J Med Chem. 2015 Mar 12;58(5):2547-2552.

[2]. Brown A, et al. Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent. Bioorg Med Chem Lett. 2010 Jan 15;20(2):516-520.