AT101 (R)-(-)-Gossypol

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Chemical Information

Product name：AT101 (R)-(-)-Gossypol	Purity：98% min
CAS NO：90141-22-3	Solubility：
Molecular Formula：C₃₀H₃₀O₈	Package：Package according to customer requirements
Molecular Weight：518.554	Storage：Store at -20℃

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Remarks

Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.

Properties:
Density: 1.403 g/cm3
Melting Point: 166-167ºC
Boiling Point: 707.9ºCat 760 mmHg
Flash Point: 395.9ºC
Storage Condition: Store at -20ºC

References

[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.

[2]. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.