Product :
Smoothened Agonist HCl SAG
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Chemical Information
Product name:Smoothened Agonist HCl SAG |
Purity:99% min |
CAS NO:912545-86-9 |
Solubility:DMSO : ≥ 38 mg/mL (77.54 mM) |
Molecular Formula:C28H28ClN3OS |
Package:Package according to customer requirements |
Molecular Weight:490.059 |
Storage:Store at -20℃ |
Remarks
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). SAG induces pathway activation independently of Ptch proteins. The Smoothened receptor (SMO) mediates signal transduction in the hedgehog pathway, which is implicated in normal development and carcinogenesis. SMO antagonists can suppress the growth of some tumours.