Product :
TH-302 Evofosfamide
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Chemical Information
| Product name：TH-302 Evofosfamide |
Purity：98% min |
| CAS NO：918633-87-1 |
Solubility：DMSO : 94 mg/mL (209.34 mM) |
| Molecular Formula：C9H16Br2N5O4P |
Package：Package according to customer requirements |
| Molecular Weight：449.036 |
Storage：Store at -20℃ |
Remarks
Evofosfamide, also known as TH-302, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI).