MGL-3196 Resmetirom

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Chemical Information

Product name：MGL-3196 Resmetirom	Purity：98% min
CAS NO：920509-32-6	Solubility：DMSO : ≥ 31 mg/mL (71.23 mM)
Molecular Formula：C₁₇H₁₂Cl₂N₆O₄	Package：Package according to customer requirements
Molecular Weight：435.221	Storage：Store at -20℃

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Remarks

Resmetirom, also known as MGL-3196, is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α).

References

[1]. Kelly MJ, et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. J Med Chem. 2014 May 22;57(10):3912-23.