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HBX-41108 924296-39-9
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Chemical Information
Product name:HBX-41108 Purity:98% min
CAS NO:924296-39-9 Solubility:Soluble in DMSO
Molecular Formula:C13H3ClN4O Package:Package according to customer requirements
Molecular Weight:266.642 Storage:Store at -20℃
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HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.

Density: 1.66g/cm3
Boiling Point: 604.9ºC at 760 mmHg
Flash Point: 319.6ºC
Refractive Index: 1.725


1: Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeutic 
opportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi: 
10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.

2: Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin 
V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura 
V, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L. Small-molecule inhibitor 
of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol 
Cancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009 
Aug 11. PubMed PMID: 19671755.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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