AdipoRon

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Chemical Information

Product name：AdipoRon	Purity：98% min
CAS NO：924416-43-3	Solubility：DMSO : ≥ 44 mg/mL (102.68 mM)
Molecular Formula：C₂₇H₂₈N₂O₃	Package：Package according to customer requirements
Molecular Weight：428.523	Storage：Store at -20℃

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Remarks

AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease.

References

[1]. Okada-Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9.

[2]. Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131.

[3]. Zhang Y, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.